Oleg Glebov
特聘教授、博导
简介
毕业于英国剑桥大学，英国布里斯托大学和伦敦国王学院博士后。主要从事突触结构和功能方面的人类神经疾病病理机制性研究、环境影响下的突触功能的机理研究、精神药物的细胞生物学机制等。研究工作多次受到奖励和资助，取得了突出的研究成果，在Nature Cell Biology、Journal of Neuroscience,、Trends in Neurosciences、FEBS Journal, Cell Reports, BMC Medicine等国际顶尖期刊上发表多篇论著。
目前任职
青岛大学神经再生与康复研究院，特聘教授
教育背景
2006年博士，剑桥大学分子生物学MRC实验室。
就业经历
2018-至今，中国青岛大学医学院神经再生与神经康复研究所教授;伦敦大学国王学院精神病学、心理学和神经科学研究所老年精神病学系讲师。
2012-2018，伦敦大学国王学院研究员。
2008-2011年，布里斯托大学研究助理(研究员)。
获奖情况和荣誉
2014 -BBSRC /国王学院火花影响奖
2011年-伦敦法律信托基金会医学研究奖章奖学金。
2008年-贝特纪念医学研究奖学金，惠康信托。
2005 -Max Perutz学生杰出研究奖，MRC LMB。
发表文章
共19篇，其中主要/第一作者15篇，*为通讯作者
1. Glebov, O.O.*, Mueller, C., Stewart, R., Aarsland, D., & Perera, G. Antidepressant drug prescription and incidence of COVID-19 in mental health outpatients: a retrospective cohort study. BMC Medicine (2023). https://doi. org/10.1186/s12916-023-02877-9 Altmetric: Top 1% of all research outputs, Top 5% of outputs for the journal. 22 news stories.
2. Kong, X., Yao, X., Ren, J. et al. tDCS Regulates ASBT-3-OxoLCA-PLOD2-PTEN Signaling Pathway to Confer Neuroprotection Following Rat Cerebral Ischemia Reperfusion Injury. Mol Neurobiol (2023). https://doi.org/10.1007/s12035-023-03504-7
3. Feng, Z., Saha, L., Dritsa, C., Wan, Q., & Glebov, O.O.* Temperature-dependent structural plasticity of hippocampal synapses. Frontiers in Cellular Neuroscience (2022). https://doi.org/10.3389/fncel.2022.1009970
4. Glebov, O.O.*, Williamson, D., Owen, D.M., Hortobá gyi, T., Troakes, C., Aarsland, D. Structural synaptic signatures of Alzheimer’ s Disease and Dementia with Lewy Bodies in the male brain. Neuropathology&Applied Neurobiology (2022). https://doi.org/10.1111/nan.12852
5. Glebov, O.O. Sub-therapeutic fluvoxamine diverts endocytic trafficking of SARS-CoV-2 spike protein: a potential mechanism for COVID-19 protection by antidepressants. Frontiers in Pharmacology (2021). https://doi.org/10.3389/fphar.2021.787261. Top 10% of all research outputs, Top 3% of outputs for the journal. Associated preprint: BioRxiv (2021). https://doi.org/10.1101/2021.06.15.448391. Top 5% of all research outputs, Top 6% of outputs for BioRxiv.
6. Feng, Z., Zhang, X., Liu N., Wang Y., Zhou Z., Glebov, O.O., Wu, T.* Promotion of neurite outgrowth and extension using injectable welded nanofibers. Chemical Research in Chinese Universities (2021). https://doi.org/10.1007/s40242-021-1104-8
7. Feng, Z. , Glebov, O. O. * Synaptic NMDA receptor signalling controls R-type calcium channel recruitment. Eur J Neurosci (2021). https://doi.org/10.1111/ejn.15250
8. Glebov, O.O. Tonic NMDA receptor signalling shapes endosomal organisation in mammalian cells. Scientific Reports (2020).https://doi. org/10. 1038%2Fs41598-020-66071-0
9. Glebov, O.O. Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing. FEBS J. (2020). https://doi.org/10.1111/febs.15369. FEBS J. Top cited article.
10. Glebov, O.O. Distinct molecular mechanisms control levels of synaptic Factin. Cell Biology International (2019). https://doi.org/10.1002/cbin.11226.
11. Glebov, O.O.,* Jackson, R., Winterflood, C., Owen, D.M., Barker, E.A., Doherty, P., Ewers, H., and Burrone, J.* Nanoscale structural plasticity of the active zone matrix modulates presynaptic function. Cell Reports(2017).https://doi.org/10.1016/j.celrep.2017.02.064.
12. Zhou, Y., Howell, F.V., Glebov, O.O., Albrecht, D., Williams, G., and Doherty, P.*Regulated endosomal trafficking of Diacylglycerol lipase alpha (DAGLα ) generates distinct cellular pools; implications for endocannabinoid signaling. Mol Cell Neurosci(2016). https://doi.org/10.1016/j.mcn.2016.08.011.
13. Glebov, O.O.*, Cox, S., Humphreys, L., and Burrone, J.*. Neuronal activity controls transsynaptic geometry. Scientific Reports (2016). https://doi. org/10. 1038/srep22703.
14. Glebov, O.O.*, Tigaret, C., Mellor, J.R., and Henley, J.M.* Clathrin independent trafficking of AMPA receptors. J. Neurosci. (2015). https://doi. org/10.1523/JNEUROSCI.3571-14.2015.
15. Henley*, J.M., Barker, E.A. & Glebov, O.O. Routes, destinations and delays: recent
advances in AMPA receptor trafficking. Trends Neurosci (2011).https://doi.org/10.1016/j.tins.2011.02.004.
16. Glebov, O.O., Bright, N.A., and Nichols, B.J.* Flotillin-1 defines a pathway of clathrin-independent endocytosis in mammalian cells. Nature Cell Biology (2006).https://doi.org/10.1038/ncb1342. Faculty 1000 Recommended article.
17. Urakov, V.N., Valouev, I.A., Kochneva-Pervukhova, N.V., Packeiser, A.N., Vishnevsky, A.Yu, Glebov, O.O., Smirnov, V.N., and Ter-Avanesyan, M.D.* N terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination. BMC Molecular Biology (2006).https://doi.org/10.1186/1471-2199-7-34.
18. Glebov, O.O., and Nichols, B.J.* Lipid raft proteins have a random distribution during localized activation of the T-cell receptor. Nature Cell Biology (2004). https://doi.org/10.1038/ncb1103. Faculty 1000 Recommended article.
19. Glebov, O.O.*, and Nichols, B.J. Distribution of lipid raft markers in live cells. Biochem. Soc. Trans. (2004). https://doi.org/10.1042/BST0320673.
