个人简介
2018年毕业于浙江大学高分子科学与工程学系,获工学博士学位。2018年8月到2020年9月,在浙江大学高分子系从事博士后研究工作。2020年10月加入青岛大学,目前主要从事智能生物医用可降解材料的改性、制备及其组织工程领域的应用。近年来,主持国家级、省级项目,入选青岛市“金种子”人才工程,在本领域TOP期刊Bioactive Materials(中科院 1 区,IF=18.9)、Biomaterials(中科院 1 区,IF=14.0)、Acta Biomaterilia (中科院 1 区,IF=9.7)等发表多篇高水平SCI研究论文,引用800余次,H因子15,其中一篇为领域TOP期刊高被引文章。连续两年(2022-2024)为Biosensors(中科院2区,IF=5.4)特刊客座编辑,多次参加领域内会议,参与著作《自适应性生物材料》(科学出版社)。
E-mail:zhangbio137@qdu.edu.cn。
工作经历
2020.10-至今 青岛大学 神经再生与康复研究院 青年卓越人才
2018.08-2020.10 浙江大学 材料科学与工程 博士后 合作导师:高长有 教授
研究方向
具有物理引导、生化信号的智能生物医用材料体系(纳米纤维、三维支架、水凝胶、纳米粒子、微球等)结合细胞、因子、药物等用于组织再生(神经、骨、皮肤等)。
主持项目
1. 国家自然科学基金青年项目:光响应形状记忆神经导管负载间充质干细胞修复周围神经缺损的研究,2022.1-2024.12
2. 山东省自然科学基金青年项目:定向活性聚酯导管的制备及其修复坐骨神经缺损的研究,2022.01-2024.12
3. 山东省中医药科技项目青年项目:负载黄芪甲苷的靶向纳米胶束的制备及其治疗大鼠脑梗的研究,2021.09-2023.09
4. 2021年青岛市“金种子”人才工程
发表论文(一作/通讯)
1. Ziming Li, Tengfei Zhao , Jie Ding, Haochen Gu, Qiaoxuan Wang, Yifan Wang, Deteng Zhang*, Changyou Gao*. A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury. Bioactive Materials. 2023,19: 550-568. (中科院 1 区,IF=18.9, 高被引)
2. Xin Sun, Jin Yang, Jie Ma, Tianchang Wang, Xue Zhao, Dan Zhu, Wenjie Jin, Kai Zhang, Xuzhou Sun, Yuling Shen, Neng Xie, Fei Yang, Xiushuai Shang, Shuai Li, Xiaojun Zhou, Chuanglong He*, Deteng Zhang*, Jinwu Wang*. Three-dimensional bioprinted BMSCs-laden highly adhesive artificial periosteum containing gelatin-dopamine and graphene oxide nanosheets promoting bone defect repair. Biofabrication. 2023, 15(2):10.1088/1758-5090/acb73e. (中科院 1 区,IF=9)
3. Deteng Zhang, Ziming Li, Haifei Shi, Yuejun Yao, Wang Du, Pan Lu, Kejiong Liang, Liangjie Hong, Changyou Gao*. Micropatterns and peptide gradient on the inner surface of a guidance conduit synergistically promotes nerve regeneration in vivo. Bioactive Materials. 2022, 9: 134-146. (中科院 1 区,IF=18.9)
4. Xing Yu#, Deteng Zhang#, Chang Liu, Zhaodi Liu, Yujun Li, Changyou Gao*, Yong Wang*. Micropatterned poly (D,L-lactide-co-caprolactone) conduits with KHIFSDDSSE peptides and NGF promote peripheral nerve repair after severe traction injury. Frontiers in Bioengineering and Biotechnology. 2021, 9:744230. (中科院 2 区,IF=5.7)
5. Deteng Zhang#, Honghao Zheng#, Keyu Geng, Jianhua Shen, Xue Feng, Peifang Xu, Yiyuan Duan, Yifan Li, Ronghuan Wu, Zhongru Gou, Changyou Gao*. Large fuzzy biodegradable polyester microspheres with dopamine deposition enhance cell adhesion and bone regeneration in vivo. Biomaterials. 2021, 272: 120783.(中科院 1 区,IF=14.0)
6. Deteng Zhang, Yuejun Yao, Yiyuan Duan, Xing Yu, Haifei Shi, Jayachandra Reddy Nakkala, Xingang Zuo, Liangjie Hong, Zhengwei Mao, Changyou Gao*. Surface-anchored graphene oxide nanosheets on cell-scale micropatterned poly(D,L lactide-co-caprolactone) conduits promote peripheral nerve regeneration. ACS Applied Material & Interface. 2020, 12: 7915-7930. (封面文章,中科院 2 区,IF=9.5)
7. Deteng Zhang, Sai Wu, Jianyong Feng, Yiyuan Duan, Dongming Xing, Changyou Gao*. Micropatterned biodegradable polyesters clicked with CQAASIKVAV promote cell alignment, directional migration, and neurite outgrowth. Acta Biomaterilia. 2018, 74: 143-155.(中科院 1 区,IF=9.7)
8. Deteng Zhang#, Weichao Yang#, Chunyang Wang, Honghao Zheng, Zhizhou Liu, Zhehan Chen, Changyou Gao. Methylcobalamin-loaded PLCL conduits facilitate the peripheral nerve regeneration. Macromolecular Bioscience. 2020, 20: 1900382-1900392.(中科院 3 区,IF=4.6)
9. Deteng Zhang, Shengjun Xu, Sai Wu, Changyou Gao*. Micropatterned poly(D,L-lactide-co-caprolactone) films entrapped with gelatin for promoting the alignment and directional migration of Schwann cells. Journal of Materials Chemistry B. 2018, 6: 1226-1237.(中科院 2 区,IF=7)
10. Deteng Zhang, Yangyang Gao, Jing Dong, Qikun Sun, Wei Liu, Shanfeng Xue, Wenjun Yang. Two-photon absorption and piezofluorochromism of aggregationenhanced emission 2,6-bis(p-dibutylaminostyryl)-9,10-bis(4-pyridylvinyl-2)anthracene. Dyes and Pigments. 2015, 113: 307-311.(中科院 2区,IF=4.5)
会议经历
1. Deteng Zhang, Changyou Gao. GO nanosheets anchored on cell-scale micropatterned PLCL conduits promote peripheral nerve regeneration. 第七届中欧生物材料大会,2019 年,广州,口头报告。
2. Deteng Zhang, Changyou Gao. Peptide gradient along micropatterned surface of poly(L-lactide-co-caprolactone) conduit for peripheral nerve repair. 国际组织工程与再生医学亚太年会(TERMIS-AP 2016)及第二届海峡两岸论坛,2016 年,台湾,口头报告。
3. Deteng Zhang, Changyou Gao. Peptide modified functionalized poly(ester carbonate)/P(LLA-CL)-blended scaffolds for peripheral nerve regeneration. 第五届中欧生物材料论坛,2015 年,杭州,最佳墙报。
4. 张德腾,高长有。表面条带化活性聚碳酸酯用于周围神经修复的研究,2015 年全国高分子学术论文报告会,墙报。